small, 2024, https://doi: 10.1002/smll.202406419
abstract
developing cost-effective, energy-saving, and eco-friendly methods to construct nanopesticides fulfill the requirement of modern agriculture. benefiting from the versatility of metal-based complexes, a facile copper-driven method is discovered for the formation of a fungicide prothioconazole nanocomplex (cu-pro) with the particle size of ≈300 ± 85 nm. interestingly, adding 0.5-1% of anionic surfactants could generate nanocomplexes within 60 ± 12 nm and form stable dispersed nanosuspensions. both nanocomplexes exhibit remarkable control efficacy against six plant pathogenic fungi, and the ec50 values are 1.4-4.8 times lower than that of prothioconazole technical concentrate (pro tc). in addition, the novel nanocomplexes demonstrate better resistance against uv irradiation and the half-lives are 3.27- and 1.56-times longer than that of pro tc, respectively. the acute toxicity of prothioconazole nanocomplexes against non-target organism zebrafish is decreased. due to the small size and chelation with metals, the uptake and accumulation of prothioconazole in wheat plant is promoted, and the metabolites prothioconazole-desthio is significantly decreased by 42-48% than that of pro tc. this metal coordination-based strategy seeks to open a new avenue for the high-throughput preparation of nanopesticides, providing an innovative toolbox for reducing the input of agrochemicals in sustainable plant protection.
small, if=13
