highlights
•the u-box e3 ligase ospub73 positively regulates broad-spectrum disease resistance
•ospub73 interacts with and promotes the degradation of the vq-motif protein osvq25
•the osvq25 mutant confers broad-spectrum disease resistance without a growth penalty
•osvq25 interacts with and suppresses the transcriptional activity of oswrky53
cell report, if: 8.109