developmental cell ，2024，
summary
the ubiquitin-proteasome system (ups) plays crucial roles in cellular processes including plant growth, development, and stress responses. in this study, we report that a pair of e3 ubiquitin , avrpiz-t-interaction protein 6 (apip6) and ipa1-interaction (ipi1), intricately target early flowering3 (elf3) paralogous proteins to control rice immunity and . apip6 forms homo-oligomers or hetero-oligomers with ipi1. both proteins interact with oself3-2, promoting its degradation to positively control resistance against the (). intriguingly, overexpression of ipi1 in nipponbare caused significantly late-flowering phenotypes similar to the oself3-1 mutant. except for late flowering, oself3-1 enhances resistance against m. oryzae. ipi1 also interacts with and promotes the degradation of oself3-1, a of oself3-2. notably, ipi1 and apip6 synergistically modulate oself3s degradation, finely tuning blast by targeting oself3-2, while ipi1 controls both disease resistance and flowering by targeting oself3-1. this study unravels multiple functions for a pair of e3 in rice.
developmental cell，if=10.7
