中国农业科学院植物保护研究所 研究员, 博士生导师, 中国农业科学院“植物病害生物防治”创新团队首席科学家，中国农业科学院青年英才“a”类入选者。2003-2007年就读于河北农业大学生命学院并获得学士学位，2007-2010年就读于中国农业科学院植物保护研究所并获得硕士学位，2010-2014年就读于中国科学院天津工业生物技术研究所并获得博士学位。2014-2017年在德国马普煤炭所manfred.t.reetz教授实验室从事博士后研究。2017年11月回国，入职中国农业科学院植物保护研究所。主要从事线虫共生细菌中抗菌活性物质的发掘、代谢途径优化以及代谢途径中关键酶的定向改造等研究。在jacs、acs catalysis、chemical science、chemical communications等学术期刊上发表文章30多篇.
e-mail: liguangyue@caas.cn
已发表文章
1. y. dong#, t. li#, s. zhang#, j. sanchis, h. yin, j. ren, x. sheng*, g. li*, m. t. reetz*. biocatalytic baeyer-villiger reactions: uncovering the source of regioselectivity at each evolutionary stage of a mutant with scrutiny of fleeting chiral intermediates. acs catalysis, 2022, 12 , 3669-3680.
2. zhao mingqi, wang miao*, zhang xiaoguang, zhu yongan, cao jing, she yongxin, cao zhen, li guangyue*, wang jing*，abd a. m. recognition elements based on the molecular biological techniques for detecting pesticides in food: a review. critical reviews in food science and nutrition, 2021, 1-24.
3. youcai qin, fenglian jia, xiaohui li, beibei li, jie ren, xiufen yang and guangyue li*. improving the yield of xenocoumacin 1 by pbad promoter replacement in xenorhabdus nematophila cb6. agriculture, 2021, 11: 1251.
4. li, g#.; qin, y#.; fontaine, n. t#.; ng fuk chong, m.; maria‐solano, m. a.; feixas, f.; cadet, x. f.; pandjaitan, r.; garcia‐borràs, m.; cadet, f., machine learning enables selection of epistatic enzyme mutants for stability against unfolding and detrimental aggregation. chembiochem. 2020, 21,1-12.
5. 李广悦, 杨秀芬. 嗜线虫致病杆菌抗菌代谢产物 xcn1 的研究进展. 中国生物防治学报 2020, 36 (1), 1-8.
6. dong, y.; li, x.; duan, j.; qin, y.; yang, x.; ren, j.; li, g*. improving the yield of xenocoumacin 1 enabled by in situ product removal. acs omega . 2020, 5（32）, 20391–20398.
7. jiaqi duan, beibei li, youcai qin, yijie dong, jie ren and guangyue li*. recent progress in directed evolution of stereoselective monoamine oxidases. bioresources and bioprocessing [j]. 2019, 6: 1-11.
8. guangyue li, yijie dong, and manfred t. reetz*. can machine learning revolutionize directed evolution of selective enzymes? adv. synth. catal [j]. 2019, 361, 2377 – 2386.
9. yijie dong#, peiyuan yao#, yunfeng cui, qiaqing wu, dunming zhu*, guangyue li*and manfred t. reetz*. manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols. biological chemistry [j]. 2019，400(3), 313-321.
10. guangyue li, marc garcia-borràs, maximilian j. l. j. fürst, adriana ilie, marco w. fraaije, k. n. houk*and manfred t. reetz*. overriding traditional electronic effects in biocatalytic baeyer-villiger reactions by directed evolution. jacs [j]. 2018, 140, 10464−10472.
11. guangyue li#, peiyuan yao#, rui gong#, jinlong li, pi liu，richard lonsdale, qiaqing wu, jianping lin*，dunming zhu* and manfred t. reetz*. simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase mao-n. chemical science [j]. 2017, 8，4093-4099.
12. guangyue li, miguel a. maria-solano, adrian romero-rivera, sílvia osuna* and manfred t. reetz*. inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution. chemical communications [j]. 2017, 53，9454-9457.
13. guangyue li, m.j. l. j. fürst, h. r. mansouri, a. k. ressmann, a. ilie, f. rudroff, m. d. mihovilovic*, m.w. fraaije* and m. t. reetz*. manipulating the stereoselectivity of the thermostable baeyer–villiger monooxygenase tmchmo by directed evolution. organic & biomolecular chemistry [j]. 2017，15，9824-9829.
14. guangyue li, jianbo wang and manfred t. reetz*. biocatalysts for the pharmaceutical industry generated by structure-guided directed evolution ofstereoselective enzymes. bioorganic & medicinal chemistry [j]. 2017, 7(26), 1241-1251.
15. guangyue li#, hui zhang#, zhoutong sun, xinqi liu and manfred t. reetz*. multiparameter optimization in directed evolution: engineering thermostability, enantioselectivity, and activity of an epoxide hydrolase. acs catalysis [j]. 2016, 6(6), 3679−3687.
16. guangyue li and manfred t. reetz*. learning lessons from directed evolution of stereoselective enzymes. org. chem. front [j]. 2016. 3, 1350-1358.
17. guangyue li#, peiyuan yao#, peiqian cong, jie ren, lei wang, jinhui feng, peter c.k. lau, qiaqing wu*,and dunming zhu*. new recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates. scientific reports [j]. 2016，6：24973.
18. guangyue li#, jie ren#, peiyuan yao,yitao duan, hailing zhang, qiaqing wu, jinhui feng, peter ck lau*, dunming zhu*. deracemization of 2-methyl-1, 2, 3, 4-tetrahydroquinoline using mutant cyclohexylamine oxidase obtained by iterative saturation mutagenesis. acs catalysis [j]. 2014, 4，903-908.
19. guangyue li, jie ren, hiroaki iwaki, dalong zhang, yoshie hasegawa, qiaqing wu, jinhui feng, peter c. k. lau* and dunming zhu*. substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines. applied microbiology and biotechnology [j]. 2014, 98(4)，1681-1689.
20. guangyue li, jie ren, qiaqing wu*, jinhui feng, dunming zhu*, yanhe ma. identification of a marine nadph-dependent aldehyde reductase for chemoselective reduction of aldehydes. journal of molecular catalysis b, enzymatic [j], 2013, 90，17-22.
