李.方方，中国农业科学院植物保护研究所研究员，硕士生/博士生导师。2009年获南京农业大学植物保护专业学士学位，2014年获浙江大学植物病理学专业博士学位。2014-2015年在浙江大学从事博士后研究，2015-2018年在加拿大农业与农业食品部先后从事博士后、助理研究员工作。2018年引进至中国农业科学院植物保护研究所植物与病毒互作组工作。
实验室以烟草、拟南芥、番茄、大豆、白菜和油菜等为实验材料，主要以世界上危害严重、种类最多的两类植物病毒：双生病毒科病毒和马铃薯y科病毒为研究对象，开展寄主植物与病毒的互作方面的研究工作。涉及的寄主途径包含dna修饰、rna修饰与降解、蛋白质翻译后修饰与降解等。发表论文/著作70余篇，其中以通讯/第一（含共同）作者在著名专业期刊发表论文50余篇（其中15篇影响因子大于10），累计影响因子超450：包括四篇molecular plant（if="27.5）、两篇nature communications （if="16.6）、两篇journal of integrative plant biology（if="11.4）、一篇plant biotechnology journal（if="13.8）、四篇new phytologist（if="9.4）等。研究成果获“中国农业科学院科学技术成果奖”1项（第一完成人）、获国家发明专利授权17项（均为第一完成人）。
先后主持国家高层次人才项目、国家重点研发青年科学家项目、国家自然科学基金国际合作重点与面上项目等项目8项，参与国家科技部973计划课题、国家自然科学基金重大/重点项目、加拿大农业部与加拿大自然科学与工程研究委员会资助的多项课题。2018年入选中国农业科学院植物保护研究所‘青年英才计划引进工程’；2019年入选‘国家海外高层次引进人才’；2020年入选“中国农业科学院巾帼建功标兵”；2021年入选农业农村部“农业科研杰出人才”培养计划，2022年荣获“第21届全国青年岗位能手标兵”；2023年荣获“第18届中国青年女科学家奖”等奖励与荣誉。兼任new plant protection执行主编、frontiers in microbiology与mpmi期刊的associate editor、中国植物病理学报副主编、frontiers in plant science等期刊的review editor等。
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代表性论文（#共同第一作者，*共同通讯作者）
(1) linhao ge, xueping zhou, fangfang li*. plant-virus arms race beyond rna interference. trends in plant science, 2024, 29(1):16-19. (通讯，if 20.5，q1)
(2) hao li#, pan gong#, xiongbiao xu, xueping zhou*, fangfang* li. knock-out of the virus replication-related genes ubef1b and ccr4/not3 by crispr/cas9 confers high-efficiency and broad-spectrum resistance to geminiviruses in nicotiana benthamiana. plant biotechnology journal, 2024, 22(4):793-795. (通讯，if 13.8，q1)
(3) jie liu#, pan gong#, ruobin lu#, rosa lozano-durán, xueping zhou*, fangfang li*. chloroplast immunity: a cornerstone of plant defense. molecular plant, 2024, doi: 10.1016/j.molp.2024.03.012. (通讯，if 27.5，q1)
(4) pan gong#, qingtang shen#, mingzhen zhang#, rui qiao, jing jiang, lili su, siwen zhao, shuai fu, yu ma, linhao ge, yaqin wang, rosa lozano-durán, aiming wang, fangfang li*, xueping zhou* plant and animal positive-sense single-stranded rna viruses encode small proteins important for viral infection in their negative-sense strand. molecular plant, 2023, 16(11), 1794-1810. (通讯，if 27.5，q1)
(5) hao he, linhao ge, yalin chen, siwen zhao, zhaolei li, xueping zhou*, fangfang li*.m6a modification of plant virus enables host recognition by nmd factors in plants. science china life sciences, 2023. (通讯，if 9.1，q1)
(6) siwen zhao#, pan gong#, hui liu, xueping zhou*, fangfang li*. geminivirus c5 proteins mediate formation of virus complexes at plasmodesmata for viral intercellular movement. plant physiology, 2023, 193(1):322-338. (通讯，if 7.4，q1)
(7) linhao ge, buwei cao, rui qiao, hongguang cui, shaofang li, hongying shan, pan gong, mingzhen zhang, hao li, aiming wang, xueping zhou*, fangfang li*. sumoylation-modified pelota-hbs1 rna surveillance complex restricts the infection of potyvirids in plants. molecular plant, 2023, 16(3):632-642. (通讯，if 27.5，q1)
(8) buwei cao, linhao ge, mingzhen zhang, fangfang li*, xueping zhou*. geminiviral c2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of atg7 and atg8. journal of integrative plant biology, 2023, 65(5):1328-1343. (通讯，if 11.4，q1)
(9) mingzhen zhang#, buwei cao#, hui zhang, zaifeng fan, xueping zhou*, fangfang li*. geminivirus satellite-encoded βc1 activates upr and induces bzip60 nuclear export to benefit virus infection. science china life sciences, 2023, 66(6):1408-1425. (通讯，if 9.1，q1)
(10) fangfang li#, linhao ge#, rosa lozano-durán, xueping zhou*. antiviral rnai drives host adaptation to viral infection. trends in microbiology, 2022, 30(10):915-917. (第一，if 15.9，q1)
(11) fangfang li#, rui qiao#; zhanqi wang; xiuling yang, xueping zhou*. occurrence and distribution of geminiviruses in china. science china life sciences, 2022, 65(8):1498-1503. (第一，if 9.1，q1)
(12) yushuang guo, meng-ao jia, shaofang li*, fangfang li*. geminiviruses boost active dna demethylation for counter-defense. trends in microbiology, 2022, 30(12):1121-1124. (通讯，if 15.9，q1)
(13) pan gong, siwen zhao, hui liu, zhaoyang chang, fangfang li*, xueping zhou*. tomato yellow leaf curl virus v3 protein traffics along microfilaments to plasmodesmata to promote virus cell-to-cell movement. science china-life sciences, 2022, 65(5):1046-1049. (通讯，if 9.1，q1)
(14) pan gong#, huang tan#, siwen zhao, hao li, hui liu, yu ma, xi zhang, junjie rong, xing fu, rosa lozano-durán*, fangfang li*, xueping zhou*. geminiviruses encode additional small proteins with specific subcellular localizations and virulence function. nature communications, 2021, 12(1):4278. (通讯，if 16.6，q1)
(15) mingzhen zhang, pan gong, linhao ge, zhaoyang chang, xiaofei cheng, xueping zhou, aiming wang, fangfang li*. nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity. new phytologist, 2021, 232(3):1382-1398. (通讯，if 9.4，q1)
(16) fangfang li*, mingzhen zhang, changwei zhang, xueping zhou. nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in solanaceous plants. new phytologist, 2020, 225(4): 1746-1761. (第一兼通讯，if 9.4，q1)
(17) fangfang li#, changwei zhang#, ziwei tang, lingrui zhang, zhaoji dai, shanwu lyu, yinzi li, xilin hou, mark bernards, aiming wang*. a plant rna virus activates selective autophagy in a upr-dependent manner to promote virus infection. new phytologist, 2020, 228(2):622-639. (第一作者，if 9.4，q1)
(18) fangfang li, aiming wang*. rna-targeted antiviral immunity: more than just rna silencing. trends in microbiology, 2019, 27(9):792-805. (第一，if 15.9，q1)
(19) fangfang li, wende liu, xueping zhou*. pivoting plant immunity from theory to the field. science china-life sciences, 2019, 62(11):1539-1542. (第一，if 9.1，q1)
(20) fangfang li, changwei zhang, yinzi li, guanwei wu, xilin hou, xueping zhou, aiming wang*. beclin1 restricts rna virus infection in plants through suppression and degradation of the viral polymerase. nature communications, 2018, 9(1):1268. (第一，if 16.6，q1)
