李.方.方，女，博士，研究员，硕士生/博士生导师。2009年本科毕业于南京农业大学植物保护专业，2014年博士毕业于浙江大学植物病理学专业。2014-2015年在浙江大学作物科学研究所开展博士后研究工作；2015-2018年在加拿大农业与农业食品部，伦敦研究与发展中心，先后从事博士后、助理研究员工作；2018年8月成为中国农业科学院植物保护研究所‘青年英才计划引进工程’入选者；2019年4月入选‘国家海外高层次引进人才’和中国农业科学院领军b类“农科英才。
李.方.方目前在植物病虫害生物学国家重点实验室-植物与病毒互作组开展研究工作。主要从事植物与病毒的互作研究，以烟草、拟南芥、番茄和油菜为植物实验材料，以世界上危害最为严重、种类最多的两类植物病毒：双生病毒科病毒和马铃薯y科病毒为研究对象，开展寄主植物与病毒的互作(双生病毒科病毒与寄主烟草和番茄的互作研究；芜菁花叶病毒与寄主拟南芥、烟草和油菜的互作研究)方面的工作。涉及的寄主途径包含dna甲基化、rna沉默、rna降解、细胞自噬、泛素-26s蛋白酶体降解系统等。围绕着植物与病毒互作的机制，解析植物病毒致病的机制，进一步挖掘出新型有效的抗病基因。近几年部分研究结果以通讯作者/第一作者身份在nature communications （1篇）、trends in microbiology（1篇）、molecular plant（1篇）、plos pathogens（3篇）、new phytologist（3篇）、plant physiology（1篇）、the plant journal（1篇）等专业杂志发表sci收录论文22篇，累计影响因子超142，他引次数超300次；以参与作者身份在trends in plant science、the plant cell、frontiers in plant science等专业杂志上发表sci收录论文8篇；以第一完成人授权专利4项；研究成果获2020年中国农业科学院科学技术成果奖（第一完成人，青年科技创新奖）；担任frontiers in microbiology、frontiers in plant science等杂志的学术编委。
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代表性论文（#共同第一作者，*共同通讯作者）
[1] yongsen cao, huanbin zhou, xueping zhou, fangfang li*. conferring resistance to plant rna viruses with the crispr/casrx system.virologica sinica (2021), https://doi.org/10.1007/s12250-020-00338-8
[2] fangfang li*, mingzhen zhang, changwei zhang, xueping zhou. nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in solanaceous plants. new phytologist (2020), 225(4): 1746-1761.
[3] fangfang li#, changwei zhang#, ziwei tang, lingrui zhang, zhaoji dai, shanwu lyu, yinzi li, xilin hou, mark bernards, aiming wang*. a plant rna virus activates selective autophagy in a upr-dependent manner to promote virus infection. new phytologist (2020),10.1111/nph.16716.
[4] hao li#, fangfang li#,*, mingzhen zhang, pan gong, xueping zhou*. dynamic subcellular localization, accumulation, and interactions of proteins from tomato yellow leaf curl china virus and its associated betasatellite. frontiers in plant science (2020),11:840.
[5] wanqin he #, jiayu wu #, yiyi ren, xueping zhou, songbai zhang, yajuan qian , fangfang li*, jianxiang wu*. highly sensitive serological approaches for pepino mosaic virus detection. journal of zhejiang university-science b (biomedicine & biotechnology) (2020), 21(10):811-822.
[6] yongsen cao, huanbin zhou, xueping zhou*, fangfang li*. control of plant viruses by crispr/cas system-mediated adaptive immunity. frontiers in microbiology (2020), 11:593700
[7] fangfang li#, xiongbiao xu#, zhenghe li, yaqin wang*, xueping zhou. identification of yeast factors involved in the replication of mungbeang yellow mosaic india virus using yeast temperature-sensitive mutants. virologica sinica (2020), 35: 120-123.
[8] fangfang li, aiming wang*. rna-targeted antiviral immunity: more than just rna silencing. trends in microbiology (2019), 27(9):792-805.
[9] fangfang li, wende liu, xueping zhou*. pivoting plant immunity from theory to the field. science china-life sciences (2019), 62(11):1539-1542.
[10] fangfang li, changwei zhang, yinzi li, guanwei wu, xilin hou, xueping zhou, aiming wang*. beclin1 restricts rna virus infection in plants through suppression and degradation of the viral polymerase. nature communications (2018), 28,9(1):1268.
[11] fangfang li, xiuling yang, david m bisaro, xueping zhou*. the βc1 protein of geminivirus-betasatellite complexes: a target and repressor of host defenses. molecular plant (2018), 11:1424-1426.
[12] fangfang li, aiming wang*. rna decay is an antiviral defense in plants that is counteracted by viral rna silencing suppressors. plos pathogens (2018), 14.8: e1007228.
[13] fangfang li, xiongbiao xu, xiuling yang, zhenghe li, xueping zhou*. identification of a cis-acting element derived from tomato leaf curl yunnan virus that mediates the replication of a deficient yeast plasmid in saccharomyces cerevisiae. viruses (2018), 10(10): 536.
[14] fangfang li, nan zhao, zhenghe li, xiongbiao xu, yaqin wang, xiuling yang, shu-sheng liu, aiming wang, xueping zhou*. a calmodulin-like protein suppresses rna silencing and promotes geminivirus infection by degrading sgs3 via the autophagy pathway in nicotiana benthamiana. plos pathogens (2017), 13(2): e1006213.
[15] sang‐ho park#, fangfang li#, justin renaud, wentao shen, yinzi li, lihua guo, hongguang cui, mark sumarah, aiming wang*. nbexpa1, an α-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection. the plant journal (2017), 2(5): 846-861.
[16] fangfang li, yaqin wang, xueping zhou*. sgs3 cooperates with rdr6 in triggering geminivirus-induced gene silencing and in suppressing geminivirus infection in nicotiana benthamiana. viruses (2017), 9 (9):247.
[17] fangfang li#, xiongbiao xu#, changjun huang, zhouhang gu, linge cao, tao hu, ming ding, zhenghe li, xueping zhou*. the ac5 protein encoded by mungbean yellow mosaic india virus is a pathogenicity determinant that suppresses rna silencing‐based antiviral defenses. new phytologist (2015), 208(2):555-569.
[18] fangfang li#, weidi wang#, nan zhao, bingguang xiao, peijian cao, xingfu wu, chuyu ye, enhui shen, jie qiu, qian-hao zhu, jiahua xie, xueping zhou*, longjiang fan*. regulation of nicotine biosynthesis by an endogenous target mimicry of microrna in tobacco. plant physiology (2015), 169(2): 1062-1071.
[19] xiaofei cheng1#*, fangfang li1#, jianyu cai, wei chen, nan zhao, yuqiang sun, yushuang guo, xiuling yang, xiaoyun wu*. artificial tale as a convenient protein platform for engineering broad-spectrum resistance to begomoviruses. viruses (2015), 7(8): 4772-4782.
[20] fangfang li, changjun huang, zhenghe li, xueping zhou*. suppression of rna silencing by a plant dna virus satellite requires a host calmodulin-like protein to repress rdr6 expression. plos pathogens (2014), 10: e1003921.
